We measured the intraocular pressure changes in forty female patients (aged from 20 to 50) without a history of ocular or cardiovascular disease who were classified physical status 1 and 2, and scheduled for elective surgery.
They were divided into 4 groups.
Group 1 (n=10); metocurime 0.03mg/kg as a priming dose and metocurine 0.27 mg/kg as a intubating dose.
Group 2(n=10); vecuronium 0.008mg/kg as a priming dose and vecuronium 0.072mg as a intubating dose.
Group 3 (n=10); vecuronium 0.008mg/kg as a priming dose and metocurine 0.27mg/kg as a intubating dose.
Group 4(n=10); metocurine 0.03mg/kg as a priming dose and vecuronium 0.072mg/kg as a intubating dose.
In this study, metocurine and vecuronium were used with the priming principle. We also measured changes in blood pressure, pulse rate and T1% of Train of four stimulation and evaluated the discomfort after the administration of the priming dose
and
the
difficulties of intubation.
@ES The results were as follows,
@EN 1) Compared with the control value, there was no increse in intraocular pressure following intubation in all four groups and intraocular pressure of 2 and 4 minutes following intubation decreased significantly in all four groups. The greatest
decrease was seen in group 3, but it was not significant when compared to the other three groups.
2) While a transient increase in blood pressure was seen in all four groups, the lowest increase was seen in group 3 as compared to the control value. Blood pressure 4 minutes following intubation decreased significantly in group 3.
3) A significant decrease in the T1% of the Train of four stimuli at one minute after administration of the intubating dose was seen in group 3 compared to the other three group.
4) Group 3 showed the lowest number of difficult intubation . In conclusion, the combination of vecuronium and metocurine with the priming principle provide optimal conditions for smooth and rapid intubation with no elevation of intraocular
pressure,
blood pressure and heart rate changes for ocular surgery.
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